Avanafil (Stendra): Working, Effectiveness, Advantages, and Safety Precautions

Avanafil, under the brand name Stendra, stands as a reliable and effective solution for erectile dysfunction. While not influencing sexual desire, it efficiently aids in achieving and maintaining erections when sexually aroused. However, it’s crucial to consult with a healthcare provider, follow dosage recommendations, and discuss any concerns or changes in health status for a safe and effective experience.

Erectile dysfunction (ED) is a common condition that affects men of various ages, and it can have a significant impact on their quality of life and relationships. Avanafil, known by its brand name Stendra, is a promising solution for those seeking an effective and fast-acting treatment for ED. In this blog post, we’ll explore the unique features and benefits of Avanafil, shedding light on why it has gained popularity among healthcare providers and patients alike.

How Avanafil Works

Avanafil’s mechanism of action is central to its effectiveness. Avanafil works by targeting the enzyme PDE5, which is responsible for regulating blood flow to the penis. When PDE5 is inhibited, it allows the blood vessels in the penis to relax and widen, facilitating a stronger and longer-lasting erection. It is important to note that avanafil will only work in the presence of sexual stimulation, as it does not have an automatic effect on the body.

Use of Avanafil

FDA-Approved Use:

  1. Erectile Dysfunction (ED): Avanafil is specifically approved for the treatment of erectile dysfunction (ED) in adult men. It is used to improve the ability to achieve and maintain an erection sufficient for sexual activity.

Off-Label Uses:

Off-label use refers to the use of a medication for purposes not approved by the FDA. While Avanafil is primarily approved for the treatment of ED, some healthcare providers may prescribe it off-label for other conditions, such as:

  1. Premature Ejaculation: 
  2. Raynaud’s Phenomenon:
  3. Pulmonary Hypertension:

Please note that off-label use of medications should only be done under the supervision and guidance of a qualified healthcare provider. They will consider the potential benefits and risks of using Avanafil for off-label purposes and make an informed decision based on the individual patient’s needs.

Advantages of Avanafil

  • Lower Risk of Visual Disturbances:
    One notable advantage of Avanafil is its lower risk of causing changes in color perception, such as seeing a blue tint, which can occur with some other ED medications. This means you can enjoy its benefits without worrying about visual disturbances.
  • Global Availability and Trustworthy Prescriptions:
    Avanafil is available in most countries and is prescribed by healthcare providers worldwide. This broad availability demonstrates its acceptance within the medical community and its ability to cater to diverse patient needs.
  • Versatility in Treatment:
    In some cases, Avanafil can be used as part of combination therapy for erectile dysfunction. This flexibility in treatment options allows healthcare providers to tailor solutions to the specific needs of their patients.
  • Efficacy:
    Clinical studies have shown that avanafil is effective in a significant percentage of men with ED. It helps them achieve and maintain an erection suitable for sexual intercourse.
  • No Impact on Sperm Count:
    If you have concerns about the impact on fertility, rest assured that Avanafil does not have a significant impact on sperm count or motility.
  • Rapid Action and Duration:
    Avanafil’s effects are typically noticeable within 15 minutes of ingestion and can last for up to 6 hours, providing a swift and sustained solution for erectile dysfunction.
  • Suitable for Older Adults:
    Avanafil’s safety and efficacy in older adults have been demonstrated, although dosage adjustments may be necessary in some cases. Age should not be a barrier to seeking effective treatment.
  • Notable for Those with Previous Side Effects:
    Avanafil may be suitable for men who have previously experienced side effects with other PDE5 inhibitors, as its unique profile may offer a different experience.

Side Effects and Considerations

Similar to all medications, Avanafil carries a potential for side effects. The most commonly reported side effects encompass mild discomforts such as Dizziness, Upset stomach or indigestion, Back Pain, stuffy or runny nose, Flushing, or redness and warmth in the face and neck, Headache.. Fortunately, these effects typically dissipate within a few hours. 

In the event that you encounter severe or persistent side effects, it is imperative to promptly consult your healthcare provider. In rare instances, Avanafil may induce priapism, a prolonged and painful erection that endures for over four hours. Should you experience an erection lasting beyond this duration, it is vital to seek immediate medical attention.

Alcohol and Grapefruit Interaction:  Limiting alcohol consumption and avoiding grapefruit products while using Avanafil is recommended to minimize the risk of side effects and interactions.

Dosage and Administration

Variety of Dosage Options: Available in 50mg, 100mg, and 200mg doses, with the recommended starting dose typically at 100mg, which can be adjusted based on individual response and tolerability.

As-Needed Basis: Avanafil is taken only when planning to engage in sexual activity, allowing users to maintain a spontaneous approach to managing erectile dysfunction.

Before using avanafil, it’s crucial to consider the following:

  1. Consult a Healthcare Provider: Erectile dysfunction can be caused by various factors, including underlying medical conditions. It’s essential to consult a healthcare provider to determine the cause and discuss the most suitable treatment options.
  2. Dosage: Avanafil is available in different doses. The appropriate dose will depend on individual factors and the severity of the condition. A healthcare provider will help determine the right dosage.
  3. Interactions: Some medications and health conditions may interact with avanafil, potentially leading to adverse effects. Inform your doctor about all the medications you are taking and any existing medical conditions.
  4. Safety Precautions: Do not use avanafil if you have a history of certain heart conditions, uncontrolled high or low blood pressure, or if you have recently had a stroke or heart attack.

Storage and Discretion

Remember to store Avanafil in its original packaging to protect it from moisture and light. Its discreet tablet form and lack of special preparation make it an excellent choice for those who value convenience.

Avanafil User Experiences from Twitter and Reddit

Real-life experiences can offer valuable insights into the effectiveness and side effects of Avanafil. Let’s take a look at some user experiences shared on Twitter and Reddit:

Twitter User @EDWarrior123: “Avanafil has been a game-changer for me. I love that it works so quickly, and I can finally enjoy a more spontaneous sex life. Minimal side effects too. Highly recommended! #EDTreatment”

Reddit User u/AvanaSuccess: “I’ve tried both Avanafil and Sildenafil. Avanafil kicks in faster, but Sildenafil lasts longer. It’s a matter of personal preference, but both have worked wonders for my ED.”

Reddit User u/NaturalApproach: “I tried natural remedies for a while, but they didn’t do much for my ED. Avanafil was the breakthrough I needed. Quick results and a boost in confidence. Worth it!”

Twitter User @HealthwiseJen: “Prescriptions are essential for ED meds like Avanafil because they’re not one-size-fits-all. A healthcare provider ensures it’s safe for your unique health profile. It’s not just about the efficacy, but your safety too. #HealthFirst #EDTreatment”

Stay Safe with Avanafil (Stendra) 100mg:

1. Consult a healthcare professional: Prior to starting Avanafil (Stendra) 100mg or any ED medication, it’s crucial to have a discussion with a healthcare provider and provide them with your medical history.
2. Obtain a valid prescription: Ensure that you purchase Avanafil (Stendra) 100mg only with a legitimate prescription from a qualified healthcare practitioner, avoiding unofficial sources.
3. Adhere to recommended dosage: Strictly follow the dosage instructions provided by your healthcare provider to minimize the risk of side effects and potential health complications.
4. Familiarize yourself with side effects: Educate yourself about possible side effects such as headaches, flushing, or upset stomach, and know how to manage them if they occur.
5. Be cautious about drug interactions: Inform your healthcare provider about all the medications you are currently taking to prevent any potentially risky drug interactions.
6. Stay allergy-aware: Seek immediate medical assistance if you experience any allergic symptoms.
7. Avoid mixing with nitrates: It is dangerous to combine Avanafil (Stendra) 100mg with nitrates, so make sure to avoid this combination.
8. Store securely: Safely store the medication out of reach of children, and never share it with others.

Other Active ingredient that use for same purpose

There are several other active ingredients used for the same purpose as avanafil. Some of the most commonly known PDE5 inhibitors used in the treatment of ED include:

Other active ingredients used for the same purpose.

Some of the most commonly known PDE5 inhibitors like Avanafil used in the treatment of ED include:

  1. Sildenafil: This is the active ingredient in Viagra.
  2. Tadalafil: Found in Cialis, it is known for its long duration of action.
  3. Vardenafil: Marketed under the brand name Levitra.
  4. Tadalafil + Dapoxetine: Some medications, like Tadapox, combine tadalafil with dapoxetine to treat both ED and premature ejaculation.

List Of Medicine That contain Avanafil As active ingredient:


At Medzpills, it is our mission to provide consumers with the best possible, scientifically-backed, and expert-reviewed information. Parry Stone, an expert in the field has reviewed this article, but we caution you that it should not be treated as a substitute for the advice of a qualified medical professional. It is a source of knowledge, potentially helpful in understanding health conditions, lab tests, medications, side effects, drug interactions, warnings, alerts, and more. To ensure the best experience and outcome, we strongly encourage you to consult with your doctor and discuss any concerns or questions you have about a particular disease or medication. Our services are meant to supplement, not replace, the invaluable relationship between doctor and patient.

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