Megalis 20 mg (Tadalafil)

Megalis 20 mg, a generic Cialis by Macleods Pharmaceuticals Pvt. Ltd., contains Tadalafil, a PDE-5 inhibitor. Primarily used to address erectile dysfunction, it helps achieve and sustain firmer erections.


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What is Megalis 20mg?

Megalis 20 mg is a generic Cialis medicine that is a product of an Indian Pharmaceutical company Macleods Pharmaceuticals Pvt. Ltd. The medicine falls in the PDE type 5 inhibitor class action medicine and has Tadalafil present in it as an active pharmaceutical ingredient.

The main use of the medicine is to treat erectile dysfunction, which is characterized by difficulty in achieving or maintaining an erection. Softer erections are an issue in which a person cannot develop a harder erection or an erection at all.

Premature ejaculation problem, on the other end, is an issue in which a person ejaculates very soon when having intercourse. The Megalis medicine will take 40-45 minutes to show its action in your body and stays active for 20-24 hours on average. The manufacturer packs the medicine in a silver foil strip which has four tablets present in it.

The shape of the tablet is biconvex and has a reddish-orange color. The tablet has Tadalafil salt in it, which is FDA approved. You can get the medicine only if you have a physician’s prescription.

Megalis 20mg quick information
Active Ingredient: Tadalafil
Prescription Required? Yes, Prescription Is compulsory.
FDA Pregnancy Category: Category B
Habit Forming: Not habit-forming
Chemical Class: Carboline Derivative
Action Class: PDE-5 inhibitors
Sleepiness: Does not cause sleepiness
Schedule: Schedule H Medicine
Expires on or after: Feb, 2025

How to use the medicine for best results?

  • You should always consume the medicine as a whole. Some people make mistakes by biting or chewing the tablet, which slows down the medicine’s working.
  • You should consume the medicine with a glassful of water. It would be best for swallowing the medicine and also suppress the side effects to an extent.
  • The medicine would work better if you consume only healthy food. Moreover, you can use the medicine before or after meals as per your choice.
  • It would help if you kept in mind to consume the medicine an hour before you are willing to have intercourse. After using the medicine it is better to get involved in sexually arousing activities that induce erection.

Megalis 20 mg details

How does Megalis 20 mg work?

The main reason erectile dysfunction issues happen in the body is PDE type 5. But you must know that PDE type 5 is released by the body to ensure the heart’s security. The body releases the hormone when the heart is at great risk due to the habits of a male, like junk food consumption, less physical activity, overthinking, etc.

When PDE5 is active in the body, it breaks down cGMP in the blood vessels. It is a vasodilator, and due to this, the blood vessels will contract. The blood cannot reach the penis and can not cause an erection.

The Tadalafil salt will activate and enter the blood vessels when you consume the medicine. The first task of the medicine is to block PDE type 5 from taking any actions. This action will give rise to cGMP, which will dilate a person’s blood vessels. Soon, a person gains a harder erection with sexual arousal, enough for satisfactory intercourse.

The next action of the salt is blocking the blood inside the penis. Due to this, the blood cannot retract easily, and you last longer when having intercourse. This way, the medicine suppresses both the symptoms of erectile dysfunction, and a person can have satisfactory intercourse.

The duration of the effect may vary from person to person. In addition, they gain the erection again if they feel like continuing the sex.

Who can use the Megalis 20 mg medicine?

  • People with erectile dysfunction issues can take the help of the Megalis 20 mg medicine. The main reason why people consume this medicine is to gain the sexual satisfaction back which they lose to the hands of erectile dysfunction.
  • People with Benign Prostatic Hyperplasia issues can also consume the Megalis 20 mg medicine. Those suffering from this issue can notice swelling in their prostate gland with symptoms like pain during urination and intercourse. The use of medicine helps in the permanent removal of the swelling and symptoms.
  • People with Pulmonary Arterial Hyperplasia issues can also take the help of this medicine. It will keep the symptoms of the issue under control, and you need to take it until you find a way to resolve it permanently.

Best dose for Megalis 20 mg

The physician will decide the best dose of Megalis 20 you must consume. They will also ensure that you are safe to use the medicine.

  • Missed dose

It is not a big deal if a person ever misses the dose. But making up for the dose is very important because it is necessary to ensure the medication’s effectiveness.. To make up for the dose, 12 hours or more must be left for the next dose. If the time is less than 12 hours, you should skip using the medicine.

  • Overdose

If you ever consume an overdose of the medicine, ensure that no side effects appear in your body. If side effects appear in your body and are uncontrollable, you must contact your physician. They will help you get rid of the side effects.

Side Effects of Megalis 20 mg

Educate yourself about possible side effects that may arise, such as: Back pain, headaches, flushing, or upset stomach, so you are prepared to address them if they occur.

Potential Side Effects of Megalis 20 mg Requiring Immediate Attention:

If you are taking Megalis 20 mg medicine and experience any of the following symptoms, it’s crucial to stop the medication and seek immediate medical assistance:

  1. Severe Headache and Nausea
  2. Shortness of Breath
  3. Sudden Vision/Hearing Loss
  4. Severe Hypotension: This indicates an abnormally low blood pressure.
  5. Swelling of Extremities
  6. Allergic Reactions: Look out for signs such as rash, swelling, or breathing difficulties.
  7. Chest Pain and Cardiovascular Issues
  8. Priapism: Painful and prolonged erection.

Megalis 20 mg: Common and Less Severe Side Effects

While the following side effects are typically less severe, it is advisable to consult with a healthcare provider to address them effectively. These common side effects may include:

  • – Mild stomach discomfort or indigestion
  • – Muscle pain, often referred to as myalgia
  • – Back pain
  • – Stuffy or runny nose
  • – Dizziness or lightheadedness
  • – Minor changes in vision, such as blurred vision or a blue-green tinge to objects
  • – Flu-like symptoms
  • – Mild to moderate headache
  • – Flushing, which can manifest as a feeling of warmth or redness in the face, neck, or chest


Below are various interactions that can occur when Megalis 20 mg medicine is combined with different medications and substances.

  1. Nitrates: Nitrates are prescribed medications to prevent chest pain. When both medicines come together(Megalis 20 mg and Nitrates), a notable decrease in blood pressure (BP) may occur.
    Examples of common nitrates that interact with Megalis 20 mg are provided below.
  • Nitrolingual (Nitroglycerin)
  • Amyl nitrate
  • Isosorbide mononitrate 
  • Isordil (Isosorbide dinitrate)
  1. Protease Inhibitors: Protease inhibitors, commonly used for viral infections such as HCV and human immunodeficiency virus, can increase the risk of side effects when combined with Megalis 20 mg.
    Examples of common protease Inhibitors that interact with Megalis 20 mg are provided below.
  • Ritonavir
  • Crixivan
  • Invirase
  • Nelfinavir
  • Reyataz (Atazanavir)
  • Darunavir
  • Fosamprenavir
  • Aptivus (Tipranavir)
  1. Alpha Blockers: Alpha blockers are commonly employed to regulate high blood pressure (BP). When taken concurrently with Megalis 20 mg, these medications work in tandem to further decrease BP by inducing muscle relaxation. The result of this combined approach is a noteworthy reduction in blood pressure.
    Examples of common alpha blockers that interact with Megalis 20 mg are provided below.
  • Cardura
  • Minipress (Prazosin)
  • Rapaflo (Silodosin)
  • Flomax (Tamsulosin)
  • Uroxatral
  1. Anti-Infective Medications: Similar to protease inhibitors, certain anti-infective medications can interact with Megalis 20 mg, potentially amplifying side effects.
  2. Alcohol and Megalis 20 mg Interactions: Alcohol, like Megalis 20 mg, can relax blood vessels, leading to a drop in blood pressure. 
  3. Grapefruit: Grapefruit and grapefruit juice can interfere with the metabolism of Megalis 20 mg, leading to an increase in its concentration in the body. This can result in a sudden drop in blood pressure.

Ensuring Your Safety When Using Megalis 20 mg

  1. Consult a Healthcare Professional: Before embarking on an ED medication regimen, it is crucial to consult a healthcare professional for personalized guidance. Be sure to disclose your medical history and any concerns you may have.
  2. Prescribed Medications Only: Always obtain Megalis 20 with a valid prescription from a qualified healthcare provider. Avoid purchasing them from unauthorized sources.
  3. Follow Dosage Instructions: To minimize the risk of side effects and potential health risks, strictly adhere to the recommended dosage instructions provided by your healthcare provider.
  4. Understand Potential Side Effects: Educate yourself about possible side effects that may arise, such as headaches, flushing, or upset stomach, so you are prepared to address them if they occur.
  5. Be Aware of Drug Interactions: Make sure to inform your healthcare provider about all medications you are currently taking, both prescription and over-the-counter, to prevent any potentially dangerous drug interactions.
  6. Monitor for Allergic Reactions: If you experience any allergic symptoms, seek immediate medical assistance.
  7. Do Not Mix with Nitrates: mixing these medicines can lead to severe health risks.
  8. Keep Medication Secure: Store this medicine in a secure place, out of the reach of children, and never share it with others.

Preventive measures

  • You must always share your complete medical history with the physician. They will ensure that you are safe to use the medicine or not.
  • The medicine is not safe for heart patients, It can directly harm their bodies.
  • Some people may experience dizziness or drowsiness after using the medicine, which could impair their ability to drive or operate heavy machinery.
  • If you are using the medicine, you should not consume alcohol or marijuana.
  • It would help if you never consumed grapefruit juice when using the medicine.
  • The medicine is unsafe for you if you consume nitrate-based or alpha-blocker medicines.
  • You must skip using the medicine if you have a fever, high blood pressure, nausea, or dizziness.

Potential Drug Substitutes

Frequently Asked Questions

  • How to store the medicine?

    1. Store the medicine at a temperature below 28 degrees Celsius.
    2. You must select a dry and dark place to store your medicine.
    3. You should always store the medicine away from direct sunlight.
  • How long does the medicine take to show its action?

The medicine will take 40-45 minutes to show its action in your body. It completely depends on the levels of issues you have in your body. You can adjust the time of medicine consumption according to the time that the medicine consumes.

Related Products


  • Drugs Approved by Central Drugs Standard Control Organisation: Drug Name, Strength, Indication. Available online: Reference Link
  • Definition & Facts for Erectile Dysfunction: Available online: Reference Link
  • How Tadalafil treats erectile dysfunction, pulmonary hypertension and benign prostate enlargement, and how to take it: Available online: Reference Link
  • Tadalafil: MedlinePlus Drug Information.  Available online: Reference Link
  • Tadalafil Interactions: Available online: Reference Link
  • Tadalafil (Oral Route) Side Effects: Available online: Reference Link


  • Medzpills aims to provide visitors with reliable, trustworthy, and expert-reviewed information. This article has been reviewed by Parry Stone, an expert in the field. However, it is important to note that the information presented should not be used as a substitute for the advice of a qualified medical professional. The information provided serves only as a source of knowledge and may not cover all aspects of health conditions, lab tests, medications, potential side effects, drug interactions, warnings, alerts, and more. It is highly recommended to consult with your doctor and address any concerns or questions you may have about a specific disease or medication. At Medzpills, we strive to supplement, rather than replace, the essential doctor-patient relationship.
Active Ingredient


Delivery Time:

6 To 15 days


Erectile Dysfunction


Macleods Pharmaceuticals Pvt. Ltd.


4 Tablets in 1 strip


20 mg

Equivalent Brand


Pharmaceutical Form


Country of origin



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