The active pharmaceutical ingredient inside the medicine is Sildenafil Citrate, which falls in the PDE-type5 inhibitor class action of the medicine. The manufacturer of the medicine is Alkem Pharmaceuticals, an Indian brand.


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What is Zenegra 100?

Zenegra 100 is an allopathic medication designed to assist men experiencing erectile dysfunction. This condition occurs when a man is unable to achieve a firm erection despite sexual arousal, resulting in a softer erection. This not only affects the individual but also creates challenges in the sexual satisfaction of both the male and their partner. The medication works by temporarily alleviating the symptoms of a softer erection, enabling individuals to engage in a gratifying sexual experience.

The active pharmaceutical ingredient inside the medicine is Sildenafil Citrate, which falls in the PDE-type5 inhibitor class action of the medicine. The manufacturer of the medicine is Alkem Pharmaceuticals, an Indian brand. They pack the medicine in a strip of 4. Each tablet in the strip is blue and oval, comprising 100 mg of Sildenafil Citrate. One important information about the medicine is that it is only available to people with a prescription for it.

Zenegra 100 quick information
Active Ingredient: Sildenafil
Prescription Required? Yes, Prescription Is compulsory.
FDA Pregnancy Category: Category B
Habit Forming: Not habit-forming
Chemical Class: Benzenesulfonamide Derivative
Action Class: PDE-5 inhibitors
Sleepiness: May cause sleepiness
Schedule: Schedule H Medicine
Expires on or after: June, 2025

Uses of Zenegra 100

  • Patients with erectile dysfunction can take the help of Zenegra 100 if the physician marks them safe. The medicine acts as a temporary relief from the issue of a softer erection, which is helpful for having better and satisfactory intercourse.

How does Zenegra 100 work?

Zenegra 100 medicine’s main task is to block the actions of PDE type5 in order to help a person achieve a harder erection. PDE type5 is a hormone released by the body when a male adopts a bunch of bad habits. The main aim of the release of PDE type5 is to ensure the safety of the heart, but in the process, the blood vessels contract. Due to this, blood is unable to reach the penis leading to a softer erection.

When a male consumes the medicine, Sildenafil enters the blood vessels, leading to the blocking of all the activities performed by PDE type5. It will lead to a rise in the levels of cGMP, which is a vasodilator. Soon, the blood vessels dilate, and a person notices a harder erection when they are sexually aroused.

Dosage Requirements

The required dose of the medicine varies from person to person, and the final decision on the dose is made by the physician a person visits. They require information about the medical history of a person and the intensity of the erectile dysfunction issues. They will use the first information to ensure whether a person is safe to use the medicine or not. The latter information will help a physician decide whether a patient needs one or two doses of Zenegra 100 mg per day. Ideally, it is one per day, taken half an hour before intercourse.


For detailed information on the interactions of Zenegra 100 with drugs, alcohol, supplements, food, and diseases, please visit the Sildenafil Interaction page.

Zenegra 100 and Alcohol/Supplements/Food Interactions

  • Alcohol (Ethanol)  and Zenegra 100

    • Increased risk of heart problems
    •  Reduced effectiveness of Zenegra 100
    • Increased risk of side effects
  • Zenegra 100 and Supplements/foods Interactions

    • Yohimbine: Drop in blood pressure.
    • L-arginine: Dangerous drop in blood pressure
    • Grapefruit juice: It Can lead to a higher risk of side effects

Zenegra 100 drug interactions

  • Major drug interactions

    •  Riociguat (Adempas)
    • Indinavir (Crixivan)
    • Nitroprusside (Nitropress)
    • Ritonavir (Norvir)
    • Nelfinavir (Viracept)
    • Ceritinib (Zykadia)
    • Adagrasib
    • Atazanavir (Reyataz)
    • Cobicistat (Tybost)
    • Idelalisib (Zydelig)
    • Darunavir (Prezista)
    • Boceprevir (Victrelis)
    • Lonafarnib (Zokinvy)
    • Erythromycin (Erythrocin)
    • Isosorbide (Isordil, Dilatrate-SR)
  • Moderate drug interactions

    • Amiodarone
    • Gabapentin
    • Warfarin
    • Pantoprazole
    • Metoprolol
    • Citalopram
    • Metformin
    • Carvedilol
    • Simvastatin
    • Levothyroxine
    • Hydrochlorothiazide
    • Atorvastatin
    • Omeprazole

Zenegra 100 disease interactions

  • Disease Interactions that are of high clinical significance.

    • pulmonary veno-occlusive disease (PVOD): Worsening symptomsof PVOD and potentially life-threatening complications.
    • Cardiovascular Disease: May experience a significant drop in blood pressure
    • Renal dysfunction: may result in drug accumulation.
  • Disease Interactions that are of less clinical significance.

    • Priapism
    • Alcoholism
    • Hearing Loss
    • Liver Disease
    • Retinitis Pigmentosa
    • Seizure Disorders

Side Effects

If you experience any side effects from Zenegra 100, please contact your healthcare provider immediately. You can refer to the comprehensive list of side effects associated with medications containing sildenafil: Full List of Side Effects for Medications Containing Sildenafil.

The following side effects necessitate prompt medical intervention.

  • Uncommon side effects:

    • Burning or aching in the bladder.
    • Tenderness in the stomach area.
    • More frequent need to urinate.
    • Nausea.
    • Painful urination.
    • Lightheadedness.
    • Priapism (painful erections)
    • Prickling, tingling, or numbness sensations.
    • Urine that is cloudy or bloody.
    • A feeling of burning or discomfort in the chest or abdomen.
  • Rare side effects:

    • Twitching of the muscles.
    • Sensitivity to light.
    • Expansion of the pupil.
    • Migraine.
    • Breast enlargement.
    • Severe or continuing nausea.
    • Cool and pale skin.
    • Seizures.
    • Fever or chills.
    • Restless sleep.
    • Decreased volume or frequency of urination.

Less serious side effects of Zenegra 100

  • The side effects most commonly discussed:

    • Muscular aches and pains.
    • Flushing.
    • Headaches.
    • Discomfort and tenderness around the eyes and cheekbones.
    • Sneezing.
    • Nasal bleeding.
    • Diarrhea.
    • Nasal congestion or runny nose.
    • Upset stomach after eating.
    • Insomnia.
  • Infrequent side effects:

    • Unpleasant sexual effects in men (persistent), such as the inability to experience an orgasm.
    • Coughing.
    • Ulcers in the mouth or on the lips.
    • Swallowing difficulty.
    • Tinnitus.
    • Difficulty breathing.
    • Enlargement of the face, hands, feet, or lower legs.
    • Poor coordination.
    • Asthma worsening.
    • Stomach pains.

Related Products


  • Sildenafil: MedlinePlus Drug Information. Available online: Reference Link
  • Sildenafil Interactions: Drugs.com. Available online: Reference Link
  • Sildenafil (Oral Route) Side Effects: Mayoclinic.org. Available online: Reference Link
  • Definition & Facts for Erectile Dysfunction: niddk.nih.gov. Available online: Reference Link


MedzPills is dedicated to providing visitors with accurate and reliable health information. This article has been carefully reviewed by an expert, Parry Stone. However, it’s important to understand that this information is not a substitute for advice from a qualified medical professional. Our information is meant to be a helpful resource, but it might not cover every aspect of health conditions, lab tests, medications, potential side effects, drug interactions, warnings, or alerts. It’s strongly recommended that you consult your doctor for any specific questions or concerns about a particular illness or medication. At MedzPills, our goal is to complement, rather than replace, the important doctor-patient relationship.

Active Ingredient

Sildenafil Citrate


Erectile Dysfunction


Alkem Pharma, India


100 mg

Equivalent Brand



4 Tablets in 1 strip

Delivery Time:

6 To 15 days


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